Vitamin A: More Than Meets the Eye

October 25, 2024

When you think of Vitamin A, you probably think of carrots and good eyesight, but there’s way more going on behind the scenes. Let’s break it down: Vitamin A comes in two main forms: Carotenoids** and Retinoids. These two powerhouses are responsible for much more than just helping you see in the dark, including supporting skin health, cell growth, DNA regulation and immune health (1, 2).

Carotenoids: Plant Precursors to Vitamin A**  

Carotenoids are a class of pigments found in plants, responsible for the vibrant red, orange, and yellow hues of many fruits and vegetables.

**While carotenoids are not technically Vitamin A, some (but not all) of them serve as precursors to this essential nutrient.

For example, beta-carotene and alpha-carotene (found in carrots, sweet potatoes, spinach, etc.) can be converted into retinol, the active form of Vitamin A.

Other carotenoids, like lycopene (found in tomatoes, grapes, cranberries, etc.) lutein (found in kale, parsley, pistachios, etc.) and zeaxanthin  (found in bell peppers, goji berries, kale, etc.) do not convert into Vitamin A but play vital roles in supporting health, primarily as antioxidants (1, 2). Antioxidants prevent aging and various diseases by donating electrons to (AKA "neutralizing") free radicals.

For example, the lycopene is a champion in fighting oxidative stress and aging. It is especially powerful for supporting heart health, male prostate health and may help reduce the risk of certain types of breast cancer (1,2).

The carotenoids lutein and zeaxanthin keep your eyes in top shape, protecting them from UV damage (1,2).

Retinoids: Your Active Animal-Based A 

On the flip side, retinoids—called preformed Vitamin A—are ready for action. They come from animal sources like liver, dairy, eggs and fish, and are essential for the following (1):

  • Immune system boost:
    • Support immune cells in fighting infections
    • Strengthen body’s protective barriers by increasing mucus production, keeping harmful bacteria in check
  • Bone health:
    • Too much or too little can mess with your bone density
  • Cancer-fighting potential:
    • Encourage proper maturation of abnormal cells, preventing them from multiplying and spreading
  • DNA Regulation:
    • Takes charge of gene expression, guiding cells on how to grow and function properly
  • Thyroid Health (3):
    • Needed for proper thyroid hormone production and metabolism
    • Binds to receptors on the cell nucleus, allowing thyroid hormone to enter and thus be active
  • Skin and gut health:
    • Supports glowing, hydrated skin
    • Maintains the lining of your gut, thus protecting against leaky gut and autoimmunity
  • Vision:
    • Form a molecule called rhodopsin in the retina, needed for night vision
    • Protect cornea and eye tissue

The Key to Absorbing Vitamin A: Fat Is Essential!

Here’s where people often make a mistake: Without enough fat, Vitamin A can’t be properly absorbed by your body. Both retinoids and carotenoids require fat to be digested and transported. So, that fat-free salad with carrots? It might taste great, but your body won’t be able to use Vitamin A effectively (1). You need at least 5 grams of fat in a meal for sufficient absorption—think about ⅓ avocado, ½ Tbsp olive oil, or 2 Tbsp almonds. 

Snacking on carrots or loading up on leafy greens is great, but without some healthy fats, their Vitamin A benefits will slip right past you!

Too Much of a Good Thing?

Like most things, balance is key. Vitamin A toxicity—or hypervitaminosis A—can happen if you go overboard, leading to symptoms like headaches, nausea, and bone pain. Interestingly, Vitamin A is stored so efficiently that your liver can hold up to 90% of your body’s reserves (4), so while overdosing through diet is rare, you are at risk if you're taking multiple supplements. I often find clients are taking overlapping supplements and getting unnatural, megadoses of nutrients that are throwing their body out of balance and doing more harm than good!

During pregnancy, excessive Vitamin A intake can be particularly dangerous, as it may cause birth defects, making it crucial to monitor intake closely.

You’re More Likely to be Slacking Than You Think! 

While severe Vitamin A deficiency is rare in the U.S., suboptimal intakes are much more common—affecting a surprising 45% of the population (5). Even mild deficiencies can still lead to noticeable issues like poor vision, weakened immunity, and dry skin. 

Those with liver issues, gallbladder problems, or those who've had their gallbladder removed are at higher risk since Vitamin A needs fat to be absorbed. The liver produces bile and the gallbladder releases it; Bile is needed to digest and absorb fat and fat soluble vitamins. If you feel heavy or sluggish after eating a high-fat meal, it might signal trouble digesting fats—and in turn, absorbing Vitamin A. These subtle problems can add up, impacting overall health (5).

The Recommended Daily Allowance (RDA) for Vitamin A is 900 mcg for men and 700 mcg for women. 

  • 10 baby carrots = 400 mcg
  • 2 eggs = 140 mcg
  • 4 oz of salmon = 50 mcg
  • ⅓ cup of cooked spinach = 380 mcg. 

Vitamin A is just one of the many essential vitamins and minerals your body needs to thrive. Wondering if you're getting the right amount—without going overboard—on all the nutrients crucial for optimal health? >> Book a free 15-minute call with me HERE << to discuss how you can achieve a balanced, nutrient-rich diet! 

References:

  1. McEldrew EP, Lopez MJ, Milstein H. Vitamin A. [Updated 2023 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482362/
  2. Johra FT, Bepari AK, Bristy AT, Reza HM. A Mechanistic Review of β-Carotene, Lutein, and Zeaxanthin in Eye Health and Disease. Antioxidants (Basel). 2020;9(11):1046. Published 2020 Oct 26. doi:10.3390/antiox9111046
  3. Capriello S, Stramazzo I, Bagaglini MF, Brusca N, Virili C, Centanni M. The relationship between thyroid disorders and vitamin A.: A narrative minireview. Front Endocrinol (Lausanne). 2022;13:968215. Published 2022 Oct 11. doi:10.3389/fendo.2022.968215
  4. Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US); 2001. 4, Vitamin A. Available from: https://www.ncbi.nlm.nih.gov/books/NBK222318/
  5. Reider CA, Chung RY, Devarshi PP, Grant RW, Hazels Mitmesser S. Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. Nutrients. 2020;12(6):1735. Published 2020 Jun 10. doi:10.3390/nu12061735 

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